Sfrp Controls Apicobasal Polarity and Oriented Cell Division in Developing Gut Epithelium
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منابع مشابه
Sfrp Controls Apicobasal Polarity and Oriented Cell Division in Developing Gut Epithelium
Epithelial tubular morphogenesis leading to alteration of organ shape has important physiological consequences. However, little is known regarding the mechanisms that govern epithelial tube morphogenesis. Here, we show that inactivation of Sfrp1 and Sfrp2 leads to reduction in fore-stomach length in mouse embryos, which is enhanced in the presence of the Sfrp5 mutation. In the mono-cell layer o...
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Thiazolidinediones have been reported to retard cystic disease in rodent models by uncertain mechanisms. We hypothesized that their major effect in retarding cystogenesis was through inhibiting cell proliferation or stimulating apoptosis. In the Madin-Darby canine kidney cell (MDCK) model, rosiglitazone inhibited cyst growth in a time- and dose-dependent manner and this was accompanied by a red...
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Asymmetric distribution of proteins and other molecules within cells leads to cell polarization. One of the most studied examples occurs in epithelial cells that polarize to form apical and basolateral surfaces (Nelson, 2003). Although we know much about directed protein trafficking after cells are polarized, less is known about the initial mechanisms that lead to polarization. Genetic and bioc...
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2009
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1000427